abstract：Background:Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a human immunodeficiency virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with new psychoactive subs...

journal_title：Open forum infectious diseases

authors： Hanke K,Fiedler S,Grumann C,Ratmann O,Hauser A,Klink P,Meixenberger K,Altmann B,Zimmermann R,Marcus U,Bremer V,Auwärter V,Bannert N

更新日期：2020-05-27 00:00:00

abstract：:Orbital actinomycosis is an unusual clinical manifestation of orbital infection caused by Actinomyces species. Herein we report a case of orbital actinomycosis in a 67-year-old woman with recurrent swelling and erythema around her left eye with an orbital mass initially thought to be a meningioma. ...

journal_title：Open forum infectious diseases

authors： Kobayashi T,Ford B,Fujita N,Appenheimer AB

更新日期：2020-05-19 00:00:00

abstract：Background:Chagas disease, caused by the parasite Trypanosoma cruzi, once considered a disease confined to Mexico, Central America, and South America, is now an emerging global public health problem. An estimated 300 000 immigrants in the United States are chronically infected with T. cruzi. However, awareness of Chaga...

journal_title：Open forum infectious diseases

authors： Zheng C,Quintero O,Revere EK,Oey MB,Espinoza F,Puius YA,Ramirez-Baron D,Salama CR,Hidalgo LF,Machado FS,Saeed O,Shin J,Patel SR,Coyle CM,Tanowitz HB

更新日期：2020-05-06 00:00:00

abstract：Background:The 4-component capsular group B meningococcal vaccine (4CMenB) was licensed as a 4-dose infant schedule but introduced into the United Kingdom as 3 doses at 2, 4, and 12 months of age. We describe the immunogenicity and reactogenicity of the 2 + 1 schedule in infants. Methods:Infants were randomized to rec...

journal_title：Open forum infectious diseases

authors： Valente Pinto M,O'Connor D,Galal U,Clutterbuck EA,Robinson H,Plested E,Bibi S,Camara Pellisso S,Hughes H,Kerridge S,Mujadidi YF,Findlow H,Borrow R,Snape MD,Pollard AJ

更新日期：2020-04-29 00:00:00

abstract：Background:Hematogenous dissemination of Talaromyces marneffei can result in multiorgan involvement (skin, lung, and reticuloendothelial system involvement); however, few studies have reported intestinal T marneffei infections. We investigated clinical features, management, and patient outcomes concerning Talaromyces-r...

journal_title：Open forum infectious diseases

authors： Pan M,Huang J,Qiu Y,Zeng W,Li Z,Tang S,Wei X,Zhang J

更新日期：2020-04-27 00:00:00

abstract：Background:Identification of HIV infection at the early stage is valuable for patient management, for prevention, and for research purposes. In practice, identification of a recent HIV infection at diagnosis proves challenging after HIV antibody seroconversion but can be suspected using Western blots (WBs) or immunoblo...

journal_title：Open forum infectious diseases

authors： Stefic K,Mahjoub N,Desouche C,Néré ML,Thierry D,Delaugerre C,Barin F,Chaix ML

更新日期：2020-04-21 00:00:00

abstract：:Chronic pulmonary histoplasmosis (CPH) is an uncommon manifestation of Histoplasma infection with features similar to pulmonary tuberculosis (TB). In endemic areas, it may be misdiagnosed as smear-negative pulmonary TB. Historical case series mainly from patients with presumed TB described a high frequency of cavitati...

journal_title：Open forum infectious diseases

authors： Baker J,Kosmidis C,Rozaliyani A,Wahyuningsih R,Denning DW

更新日期：2020-04-06 00:00:00

abstract：Background:Hydatid disease is a severe health problem in endemic areas. In recent years, the incidence of this disease in China has been increasing. As the imaging characteristics of pancreatic echinococcosis (PE) are similar to those of cystic diseases, such as cysts, tuberculosis, and tumors, PE is often misdiagnosed...

journal_title：Open forum infectious diseases

authors： Gou L,Gao F,Tiheiran M,Guo H

更新日期：2020-04-03 00:00:00

abstract：:The year 2019 brought about a multitude of innovations in clinical infectious diseases. With the continued rise of antimicrobial resistance (AMR), advances in diagnostics and newly available antibiotics offer additional strategies for combating this threat, but the broken antibiotic market serves as an impediment to f...

journal_title：Open forum infectious diseases

authors： Moss S,Boucher HW

更新日期：2020-03-23 00:00:00

abstract：:We treated three pediatric cardiac transplant patients with chronic parvovirus viremia with high-dose intravenous immunoglobulin (HD-IVIG). One patient with severe T-cell lymphopenia suffered recurrent viremia and aseptic meningitis, which resolved remarkably when he was switched to high-dose hyaluronidase-facilitated...

journal_title：Open forum infectious diseases

authors： Cruz RJ,Dasso JF,Duff C,Krasnopero D,Long Z,Ellison M,Nieves D,Sriaroon P,Asante-Korang A,Walter JE

更新日期：2020-03-12 00:00:00

abstract：:Patients with Mycobacterium avium complex lung disease treated with amikacin liposome inhalation suspension (ALIS) at 2 clinics in the United States were surveyed to assess the frequency and management of ALIS-associated respiratory adverse events. Most respondents experienced these events, but management through phys...

journal_title：Open forum infectious diseases

authors： Swenson C,Lapinel NC,Ali J

更新日期：2020-03-02 00:00:00

abstract：:This is a single-center retrospective observational cohort study comparing daptomycin/ceftaroline combination therapy with rifampin-adjunct therapy for the treatment of staphylococcal device infections. The results of this study support use of the daptomycin/ceftaroline as an alternative or salvage option to standard ...

journal_title：Open forum infectious diseases

authors： Chang AT,Cosimi RA,Bochan MR

更新日期：2020-02-28 00:00:00

abstract：Background:Human babesiosis is a common zoonosis caused by Babesia and is attracting an increasing concern worldwide. The natural course of babesiosis infection and how the human immune system changes during the course of babesiosis infection are not clear. Methods:We followed up 1 case infected with Babesia venatorum...

journal_title：Open forum infectious diseases

authors： Zhao L,Jiang R,Jia N,Ning N,Zheng Y,Huo Q,Sun Y,Yuan T,Jiang B,Li T,Liu H,Liu X,Chu Y,Wei R,Bian C,Wang H,Song J,Wang H,Jiang J,Cao W

更新日期：2020-02-18 00:00:00

abstract：Background:Coagulation activity among persons with HIV is associated with end-organ disease risk, but the pathogenesis is not well characterized. We tested a hypothesis that hypercoagulation contributes to disease risk, in part, via upregulation of inflammation. Methods:Treatment effects of edoxaban (30 mg), a direct ...

journal_title：Open forum infectious diseases

authors： Baker JV,Wolfson J,Peterson T,Mooberry M,Gissel M,Mystakelis H,Henderson MW,Garcia-Myers K,Rhame FS,Schacker TW,Brummel-Ziedins KE,Sereti I,Key NS,Tracy RP

更新日期：2020-02-01 00:00:00

abstract：Background:Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment of complicated urinary tract infections (UTI). The purpose of this study was to characterize the patients, infections, drug susceptibilities, and outcomes of multiple-dose fosfomycin episodes for ou...

journal_title：Open forum infectious diseases

authors： Derington CG,Benavides N,Delate T,Fish DN

更新日期：2020-01-29 00:00:00

abstract：:In a 2016 survey of 46 Michigan hospitals, we identified four key needs for antibiotic stewardship: clinically-relevant antibiotic data, monitoring compliance, syndrome-specific interventions, and discharge stewardship. A stewardship initiative now addresses these needs within the Michigan Hospital Medicine Safety Con...

journal_title：Open forum infectious diseases

authors： Vaughn VM,Petty LA,Flanders SA,Malani AN,Patel T,Bernstein SJ,Hsaiky LM,Thyagarajan R,Osterholzer D,McLaughlin E,Horowitz JK,Gandhi TN

更新日期：2020-01-11 00:00:00

abstract：:Lyme disease accounted for more than two-thirds (56 of 81, 69.1%) of all tick-borne disease referrals to a large, academic infectious diseases clinic in a low-incidence state. Deviations from diagnostic testing guidelines and errors in test interpretation were common (23 of 35, 65.7%), suggesting that frontline provid...

journal_title：Open forum infectious diseases

authors： Boyce RM,Speight C,Lin JT,Farel CE

更新日期：2020-01-11 00:00:00

abstract：Background:The use of a "trial of antibiotics" as empiric therapy for bacterial pneumonia as a diagnostic tool for tuberculosis in people with HIV (PWH) was removed from World Health Organization (WHO) recommendations in 2007, based on expert opinion. Current guidelines recommend antibiotics only after 2 Xpert MTB/RIF ...

journal_title：Open forum infectious diseases

authors： Boyles TH,Nduna M,Pitsi T,Scott L,Fox MP,Maartens G

更新日期：2020-01-06 00:00:00

abstract：:Francisella tularensis has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. ...

journal_title：Open forum infectious diseases

authors： Nelson CA,Brown J,Riley L,Dennis A,Oyer R,Brown C

更新日期：2019-11-19 00:00:00

abstract：:We engaged medical students with antimicrobial stewardship (AS) and antimicrobial resistance (AMR) through patient stories and a panel on AMR advocacy with experts from the Centers for Disease Control and Prevention and the Infectious Diseases Society of America. Students were surveyed on their perceptions about AS an...

journal_title：Open forum infectious diseases

authors： Nori P,Cowman K,Jezek A,Nosanchuk JD,Slosar-Cheah M,Sarwar U,Bartash R,Ostrowsky B

更新日期：2019-11-13 00:00:00

abstract：Background:In human immunodeficiency virus (HIV) treatment, tenofovir alafenamide (TAF) is associated with greater increases in all fasting cholesterol subgroups compared with tenofovir disoproxil fumarate (TDF). Because lipid abnormalities may contribute to cardiovascular morbidity and mortality, cardiovascular risk a...

journal_title：Open forum infectious diseases

authors： Huhn GD,Shamblaw DJ,Baril JG,Hsue PY,Mills BL,Nguyen-Cleary T,McCallister S,Das M

更新日期：2019-11-11 00:00:00

abstract：Background:Cytomegalovirus retinitis is a treatable cause of blindness in people with human immunodeficiency virus (HIV) typically with CD4 counts <50 cells/mm3. Diagnosis is with indirect fundoscopy, and treatment is with intravitreal ganciclovir injections or systemic therapy. However, diagnosis and treatment are not...

journal_title：Open forum infectious diseases

authors： Ocieczek P,Barnacle JR,Gumulira J,Phiri S,Heller T,Grabska-Liberek I

更新日期：2019-11-06 00:00:00

abstract：:A 7-year-old child of Turkish origin presented with headache and vomiting in the context of prolonged fever of unknown source. At examination, oral candidiasis and chronic onychomycosis were noted. A Candida meningoencephalitis was diagnosed and intravenous Amphotericin B liposomal was given during 6 months relayed by...

journal_title：Open forum infectious diseases

authors： Martin S,Balligand E,Peeters J,Nassogne MC,Mondovits B,Loop M,de Selys A,Vanclaire J,Vermylen C,De Bruyckere JJ,Chatzis O,Puel A,Gilliaux O,Van Der Linden D

更新日期：2019-11-03 00:00:00

abstract：:Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report succes...

journal_title：Open forum infectious diseases

authors： Canfield GS,Henao-Martínez AF,Franco-Paredes C,Zhelnin K,Wilson ML,Shihadeh KC,Wyles D,Gardner EM

更新日期：2019-10-23 00:00:00

abstract：Background:This study aims to estimate the disease burden of vertically acquired hepatitis C virus (HCV) in a large Midwestern hospital and to identify factors associated with HCV diagnostic testing among high-risk infants. Methods:This is a retrospective analysis of an infant cohort (n = 58 427) born from 2014 to 201...

journal_title：Open forum infectious diseases

authors： Protopapas S,Murrison LB,Wexelblatt SL,Blackard JT,Hall ES

更新日期：2019-10-21 00:00:00

abstract：Background:Irritable bowel syndrome (IBS) is a chronic and debilitating functional gastrointestinal disorder affecting 9%-23% of the population across the world. The relative efficacy of fecal microbiota transplantation (FMT) on IBS symptoms was demonstrated in a double-blind, randomized study. Methods:We describe the...

journal_title：Open forum infectious diseases

authors： Hocquart M,Pham T,Kuete E,Tomei E,Lagier JC,Raoult D

更新日期：2019-10-14 00:00:00

abstract：Background:Antimicrobial stewardship interventions utilizing real-time alerting through the electronic medical record enable timely implementation of the bundle of care (BOC) for patients with severe infections, such as candidemia. Automated alerting for candidemia using the Epic stewardship module has been in place si...

journal_title：Open forum infectious diseases

authors： Pettit NN,Han Z,Nguyen CT,Choksi A,Charnot-Katsikas A,Beavis KG,Tesic V,Pisano J

更新日期：2019-10-11 00:00:00

abstract：:A patient with multiple sclerosis presented with seronegative C. burnetii endocarditis diagnosed using C. burnetii-specific polymerase chain reaction and fluorescence in situ hybridization on cardiovascular biopsy. This case supports the necessity of a systematic polymerase chain reaction testing of removed cardiac va...

journal_title：Open forum infectious diseases

authors： Melenotte C,Loukil A,Rico A,Lepidi H,Raoult D

更新日期：2019-10-04 00:00:00

abstract：Background:Molecular detection methods allow for the simultaneous detection of several infectious agents. This study assesses whether co-infection with 2 viruses as compared with 1 is associated with increased hospitalization in those with acute respiratory infections. Methods:We prospectively enrolled a cohort of ped...

journal_title：Open forum infectious diseases

authors： Noyola DE,Hunsberger S,Valdés Salgado R,Powers JH 3rd,Galindo-Fraga A,Ortiz-Hernández AA,Ramirez-Venegas A,Moreno-Espinosa S,Llamosas-Gallardo B,Guerrero ML,Beigel JH,Ruiz-Palacios G,Perez-Patrigeon S,Mexico Emerging Infectious

更新日期：2019-10-03 00:00:00

abstract：:In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophag...

journal_title：Open forum infectious diseases

authors： Audemard-Verger A,Gasnault J,Faisant M,Besse MC,Martin-Silva N,Berra M,Fournier L,Boutemy J,Maigne G,De Boysson H,Ruet A,Vabret A,Chapon F,Martin-Blondel G,Aouba A

更新日期：2019-09-30 00:00:00

abstract：Background:Bolstered by the high efficacy of hepatitis C virus (HCV) treatment, the World Health Organization has called for HCV elimination by 2030. People with HIV (PWH) have been identified as a population in which elimination should be prioritized. Methods:We examined progress in HCV elimination through the HCV ca...

journal_title：Open forum infectious diseases

authors： Falade-Nwulia O,Sutcliffe CG,Mehta SH,Moon J,Chander G,Keruly J,Katzianer J,Thomas DL,Moore RD,Sulkowski MS

更新日期：2019-09-30 00:00:00

abstract：Background:Pharmacists with residency training in infectious diseases (ID) optimize antimicrobial therapy outcomes in patients and support antimicrobial stewardship (AS) programs. Although most ID residencies are accredited and assessed by certain standards, the degree to which these programs are similar is not known. ...

journal_title：Open forum infectious diseases

authors： Cho JC,Crotty MP,Kufel WD,Chahine EB,Sofjan AK,Gallagher JC,Estrada SJ

更新日期：2019-09-06 00:00:00

abstract：BACKGROUND:Among the 1.2 M persons living with HIV in the United States, 25% are co- infected with HCV. The availability of effective direct antiviral agents (DAAs) makes the goal of HCV elimination feasible, but implementation requires improvements to the HCV treatment cascade, especially linkage to and initiation of ...

journal_title：Open forum infectious diseases

authors： Rizk C,Miceli J,Shiferaw B,Malinis M,Barakat L,Ogbuagu O,Villanueva M

更新日期：2019-08-14 00:00:00

abstract：BACKGROUND:Postoperative infections are a common and often preventable complication of surgery. S. aureus is a prevalent organism cultured in these infections and is associated with morbidity, mortality, and increased healthcare utilization. However, the long-term burden of S. aureus infection in surgical patients is n...

journal_title：Open forum infectious diseases

authors： O'Brien WJ,Gupta K,Itani KMF

更新日期：2019-08-13 00:00:00

abstract：:Naegleria fowleri is a thermophilic free-living amoeba that is found in warm, fresh water and causes primary amebic meningoencephalitis (PAM). The following report demonstrates the rapid and destructive clinical features of PAM in an 8-year-old male who presented with severe headaches approximately 12 days after swimm...

journal_title：Open forum infectious diseases

authors： Vareechon C,Tarro T,Polanco C,Anand V,Pannaraj PS,Dien Bard J

更新日期：2019-07-29 00:00:00

abstract：Background:The diagnosis of cellulitis is made clinically without a gold standard diagnostic test, and cellulitis has many disease mimics. There is currently no consensus for optimal antimicrobial treatment duration or method of antimicrobial delivery. Methods:This was a randomized controlled open-label multicenter tr...

journal_title：Open forum infectious diseases

authors： Clarke MC,Cheng AC,Pollard JG,Birch M,Cowan RU,Linke JA,Walton AL,Friedman ND

更新日期：2019-07-20 00:00:00

abstract：Background:We characterized the extent of antiretroviral therapy (ART) experience and postdischarge mortality among hospitalized HIV-infected adults in Zambia. Methods:At a central hospital with an opt-out HIV testing program, we enrolled HIV-infected adults (18+ years) admitted to internal medicine using a population...

journal_title：Open forum infectious diseases

authors： Haachambwa L,Kandiwo N,Zulu PM,Rutagwera D,Geng E,Holmes CB,Sinkala E,Claassen CW,Mugavero MJ,Wa Mwanza M,Turan JM,Vinikoor MJ

更新日期：2019-07-16 00:00:00

abstract：:Latent Epstein-Barr virus (EBV) infection can clinically reactivate in immunosuppressed individuals causing lymphoproliferative disease and rarely hepatitis. In this study, we provide in vivo and in vitro evidence that Treponema pallidum infection can cause EBV reactivation with hepatitis in an immunocompetent patient...

journal_title：Open forum infectious diseases

authors： Hirsiger JR,Fuchs PS,Häusermann P,Müller-Durovic B,Daikeler T,Recher M,Hirsch HH,Terracciano L,Berger CT

更新日期：2019-07-03 00:00:00

abstract：BACKGROUND:Disseminated strongyloidiasis in solid organ transplant recipients is a rare but devastating infection. In our center, we implemented a universal screening of all candidates for kidney transplantation. We assessed the seroprevalence and utility of universal screening for strongyloidiasis in our center. METH...

journal_title：Open forum infectious diseases

authors： Al-Obaidi M,Hasbun R,Vigil KJ,Edwards AR,Chavez V,Hall DR,Dar WA,De Golovine A,Ostrosky-Zeichner L,Bynon JS,Nigo M

更新日期：2019-07-01 00:00:00

abstract：Background:New approaches are needed to provide care to persons with HIV who do not engage in conventionally organized HIV clinics. The Max Clinic in Seattle, Washington, is a walk-in, incentivized HIV care model located in a public health STD clinic that provides care in collaboration with a comprehensive HIV primary ...

journal_title：Open forum infectious diseases

authors： Dombrowski JC,Galagan SR,Ramchandani M,Dhanireddy S,Harrington RD,Moore A,Hara K,Eastment M,Golden MR

更新日期：2019-06-26 00:00:00